On April 13, 2022, fourteen Penn-Trafford seniors committed to continuing their athletic and academic careers at the collegiate level.
| Hannah Allen | Washington & Jefferson College | Softball |
| Sydney Andrews | Saint Vincent College | Volleyball |
| Chloe Bonson | Allegheny College | Cross Country & Track |
| Maleiah Colby | Washington & Jefferson College | Swimming |
| Ian DeMeri | Grove City College | Football |
| Luke Jollie | Grove City College | Football |
| Taylor Jones | Westminster College | Soccer |
| Garrett Mattes | Saint Vincent College | Football |
| Garrett Moorhead | Case Western Reserve | Football |
| Declan Ochendowski | Cornell University | Football |
| Madison Rapp | Geneva College | Softball |
| McKenzie Rapp | Geneva College | Softball |
| Maura Suman | Edinboro University | Basketball |
| A.J. Visco | California University of PA | Soccer |
(Front) Luke Jollie, Declan Ochendowski, Garrett Moorhead, Sydney Andrews, A.J. Visco, (Back) Ian DeMeri, McKenzie Rapp, Hannah Allen, Maura Suman, Taylor Jones, Chloe Bonson, Maleiah Colby, Madison Rapp, Garrett Mattes